The group tries to get rid of a mouse in Jimmy's house; Gretchen finally opens up to Jimmy about her mental issues.
Jimmy and Gretchen find Dorothy at breakfast with the weekend Bloody Mary ration already drunk and no food available.
Traffic is snarled by a marathon run so they can't go to the diner or the store. Gretchen starts drinking and dancing to conceal her blues.
Jimmy starts hunting a mouse that is in the house. Lindsay arrives to complain about Becca's attitude to her, and Vernon "honking her boob" in the previous episode. Vernon arrives, looking for Lindsay to get her to keep quiet about the honking.
Jimmy obsesses over catching the mouse while Gretchen keeps drinking. She finally loses it and puts everybody down one by one, except Vernon who is "not worth it". The mouse appears at her feet and she drops a copy of Jimmy's novel on it. Jimmy and the gang decide to euthanize the mouse on his car exhaust while Gretchen recovers with Lindsay's help.
Gretchen admits to Jimmy that she has been handling depression for years, but he can't fix her. As they embrace Jimmy spots another mouse.